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Clinical Trials

Discovery & Development Business Practice

Accelerate liquid formulation development for protein biopharmaceuticals

The work presented here illustrates how Differential Scanning Calorimetry (DSC) is used in the early stages of protein characterization to rapidly provide critical data about protein stability that can be used as a guide to support and accelerate liquid formulation.

Discovery & Development Clinical Trials

Clinical Trial Tragedy

A clinical trial of an FAAH inhibitor in France goes terribly wrong, but whether the compound or manufacturing are to blame remains to be seen

Discovery & Development Clinical Trials

A Brave New Year

| Stephanie Vine

How do we move on from a sombre start to 2016?

Manufacture Business Practice

Binding thermodynamics of substituted diaminopyrimidine renin inhibitors

| Sponsored by Malvern Panalytical

See how thermodynamics can be used to improve your lead optimization process.

Business & Regulation Business Practice

The Realities of a Digital World

Advanced digital technologies are sweeping through the world and changing the way we live our lives and do business.

Manufacture Business Practice

Utilization of kinITC in AFFINImeter

| Sponsored by Malvern Panalytical

This application note describes how and when can kinetic information be retrieved from ITC power curves.

Discovery & Development Clinical Trials

Cancer Complexity

| James Ritchie

Clinical development is outmoded; we are witnessing serious attrition in cancer R&D. Perhaps it’s time to live and die by the mantra: “no biomarker, no trial”.

Discovery & Development Clinical Trials

The Cautious Comeback of Oral Peptides

| David J. Brayden

Despite clinical failures in the 1990s, pharma is (cautiously) ready to try again with oral peptide formulations.

Discovery & Development Clinical Trials

Clinical Trial Clarity

| Charlotte Barker

Drug makers and regulators are taking steps towards transparency, but is it enough?

Manufacture Business Practice

Nanoparticle Tracking Analysis: Principles and Methodology

It is well established that the use of nanotechnology in medicine and more specifically drug delivery is spreading rapidly.

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