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Discovery & Development Business Practice, Drug Delivery, Ingredients, Formulation, Trends & Forecasts

Measuring Low-Level Polymorphic Contamination using Morphologically Directed Raman Spectroscopy

sponsored by Malvern Panalytical

Introduction

Interest in studying mixed systems of pharmaceutical relevance is not a new concept.  From intrinsic polymorphism to complex final products, the challenges encountered by modern analytical scientists have multiplied both in number and in complexity.  Established techniques are often unable to provide both separation and identification of species in a mixed system, as they are used to probe chemistry (bulk spectroscopy), or individual particle characteristics (microscopy and SEM).  Combining techniques capable of analyzing micron-scale particulates with absolute chemical specificity provides a new window into describing the complicated mixtures common in today’s competitive pharmaceutical market.

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