Malvern Panalytical

Polymorphic conversions are an ongoing problem in the pharmaceutical industry.

In this white paper, we report the use of the thermal stability data obtained from DSC to screen conditions for viral inactivation of an antibody1.

See how thermodynamics can be used to improve your lead optimization process.

In Part Four, we address frequently asked questions related to the application of DLS to the characterization of protein therapeutic formulations.

In Part Three, we cover the basic types of DLS deconvolution algorithms used to extract the intensity weighted particle size distribution from the measured correlogram.

In Part Two, we cover the influence of concentration effects and particle interactions on DLS results and provide a roadmap for identifying and distinguishing each type of concentration effect.

In Part One, we provide an overview of the key principles of DLS: theory, correlation statistics, deconvolution algorithms, and the intensity to mass transform.

Use of a novel combination of dynamic light scattering and Raman spectroscopy to elucidate the conformational stability and structure of proteins in biopharmaceutical formulations

Two antibody samples were characterized using column calibration and multi-detection SEC, and the results compared...

This application note describes how and when can kinetic information be retrieved from ITC power curves.

Use of static and dynamic light scattering to characterize the stability of lysozyme in the presence and absence of arginine.

How spray formulations and devices interact to impact drug delivery performance

Time-saving automation for exosomes analysis

This paper shows the degree to which the technique of NTA can be used for the characterization of nanobubbles and other ultrafine bubbles.

This study demonstrates how DSC can be a useful tool in stability screening of engineered proteins

SAXS for particle size distribution analysis of colloidal gold nanoparticles

MDRS used to demonstrate pharmaceutical equivalence

Concentration measurement and sizing of bacteriophages and viruses

This buyer's guide discusses the available instrumentation for protein stability characterization, and what to consider when choosing stability assays. Protein stability and higher order structure is used to assist with biocomparability studies.

This white paper examines the issue of counterfeit drugs, reviewing the various types produced and the nature and range of the damage they cause. The report then focuses on analytical methods for tackling the problem, in particular the use of X-ray powder diffraction (XRPD).