Cookies

Like most websites The Medicine Maker uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Discovery & Development Advanced Medicine

Results That Last

Imagine treating Alzheimer’s disease (AD) at the genetic level. Now consider researchers at Sangamo Therapeutics who have found that gene regulation therapy helps prevent the build-up of tau protein in the brain (1).

“The tau protein is predominantly found in neurons. One of tau’s main functions is to stabilize the microtubules – small structures within the nerves – that are important to ensure impulses are conducted between neurons,” says Amy Pooler, Head of Neuroscience at Sangamo. “In AD, the tau protein is abnormal and tangles into various forms of toxic aggregates that disrupt communication between neurons, and ultimately lead to cell death.”

The team decided to attempt lowering expression of the tau gene at the transcriptional level using gene-repressing zinc finger protein transcription factors (ZFP-TFs) – and observed specific, durable, and controlled reduction of endogenous tau production.

“With our ZFP-TFs, we have the potential to shift the treatment paradigm for AD from symptom management to lasting cures,” says Pooler.

Sangamo Chief Scientific Officer, Jason Fontenot hopes the research can be applied to other debilitating neurological disorders – and the company has formed partnerships with the likes of Biogen and Novartis to look at how the approach can be applied to other therapeutic areas. Fontenot says, “Genome regulation is just one tool in our genomic medicines kit. Though our collaborations in this space just kicked off this past year, we are encouraged by our progress in moving the research forward.”

Subscribe to The Medicine Maker Newsletters

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].

  1. S Wegmann et al., Science Advances  (2021). DOI: 10.1126/sciadv.abe1611

About the Author

Maryam Mahdi

Associate Editor

After finishing my degree, I envisioned a career in science communications. However, life took an unexpected turn and I ended up teaching abroad. Though the experience was amazing and I learned a great deal from it, I jumped at the opportunity to work for Texere. I'm excited to see where this new journey takes me!

Register to The Medicine Maker

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine

Register