Cookies

Like most websites The Medicine Maker uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Manufacture Analytical Science, Bioprocessing - Upstream & Downstream

The New Antibody Formats on the Block

sponsored by Tosoh

Over the last fifteen years, monoclonal antibodies (mAbs) have dominated the market but, today, alternative antibody formats are coming through company pipelines, including mAb fragments, single-chain fragment antibodies, and modified antibodies, such as antibody drug conjugates (ADCs), engineered antibodies and bi-specific antibodies.

For conventional mAbs, pharma companies tended to have one platform process for all (or the majority of) products. But these same platforms are not optimized, or simply do not work, for other antibody formats. In short, manufacturers are facing significant challenges. For example, for mAbs production, protein A was used as capture chromatography resin in purification platforms, as it interacts with the FC part of a mAb, but what about antibody fragments? Well, fragments lack the FC part, so there is no interaction with protein A! To capture mAb fragments, there has been a need for innovative chromatographic media, such as Protein L, which binds to a different part. To that end, we launched our protein L resin (Toyopearl AF-rProtein L-650F) to help manufacturers adapt to newer antibody formats coming through pipelines.

Read the full article now

Log in or register to read this article in full and gain access to The Medicine Maker’s entire content archive. It’s FREE and always will be!

Login

Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine
Register

Or Login via Social Media

By clicking on any of the above social media links, you are agreeing to our Privacy Notice.

About the Author

Patrick Endres

Patrick Endres is Senior Laboratory Specialist at Tosoh Bioscience, Germany.

Register to The Medicine Maker

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine

Register