Subscribe to Newsletter
Manufacture Business Practice, Drug Delivery, Formulation, Small Molecules, Trends & Forecasts

Using Differential Scanning Calorimetry (DSC) to optimize antibody manufacturing

sponsored by Malvern Panalytical

This information provides a quick and easy stability assay during the manufacturing process. For the antibody studied here, the apparent Tm data from DSC was key to the recommendation to increase storage pH immediately after viral inactivation, resulting in increased structural stability. This example illustrates the crucial role of DSC and thermodynamic analysis during therapeutic protein development.


There are many challenges to overcome when developing manufacturing processes for proteins intended as therapeutics. Most notably, project timelines and limited initial availability of material drive the need for rapid, robust, and sensitive process development tools. Manufacturing steps are routinely evaluated and optimized to improve protein yield, reduce production time, and increase long-term stability of final drug product. Any improvements in final yield and stability are vastly important in both process and manufacturing economics. Conversely, a failure at any step in production, resulting in decreased yield and/or stability, will result in a financial loss.

Receive content, products, events as well as relevant industry updates from The Medicine Maker and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

Register to The Medicine Maker

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine