Measuring degradation related changes in molecular weight and rheology during processing
contributed by Malvern Panalytical |
Understanding and minimizing polycaprolactone degradation during processing using multi-detector GPC and rheology
In this application note, a commercially available sample of PCL was extruded alone and in the presence of CO2. Multi-detector GPC measurements were made of the virgin sample before and after extrusion, while rotational rheometry was used to study the polymer’s melt viscosity.
Polycaprolactone (PCL) is a synthetic polymer that has recently received increasing attention thanks to its biodegradability. Its most common use is in the manufacture of polyurethanes or as a plasticizer for other polymers such as PVC. It is also often used in molding and prototyping thanks to its low melting temperature and is used as a feedstock in some additive manufacturing (3D printing) systems. Finally, it is also used in some drug delivery applications as a control release mechanism, in the same way as polylactic acid (PLA) or polylacticco-glycolic acid (PLGA). A potential advantage over PLA and PLGA is that PCL has a slower degradation rate and therefore may allow for slower drug release.
Read the full article now
Log in or register to read this article in full and gain access to The Medicine Maker’s entire content archive. It’s FREE and always will be!
Or register now - it’s free and always will be!
You will benefit from:
- Unlimited access to ALL articles
- News, interviews & opinions from leading industry experts
- Receive print (and PDF) copies of The Medicine Maker magazine
Or Login via Social Media
By clicking on any of the above social media links, you are agreeing to our Privacy Notice.