Subscribe to Newsletter

Measuring degradation related changes in molecular weight and rheology during processing

Understanding and minimizing polycaprolactone degradation during processing using multi-detector GPC and rheology


In this application note, a commercially available sample of PCL was extruded alone and in the presence of CO2­. Multi-detector GPC measurements were made of the virgin sample before and after extrusion, while rotational rheometry was used to study the polymer’s melt viscosity.


Polycaprolactone (PCL) is a synthetic polymer that has recently received increasing attention thanks to its biodegradability. Its most common use is in the manufacture of polyurethanes or as a plasticizer for other polymers such as PVC. It is also often used in molding and prototyping thanks to its low melting temperature and is used as a feedstock in some additive manufacturing (3D printing) systems. Finally, it is also used in some drug delivery applications as a control release mechanism, in the same way as polylactic acid (PLA) or polylacticco-glycolic acid (PLGA). A potential advantage over PLA and PLGA is that PCL has a slower degradation rate and therefore may allow for slower drug release.

Read the full article now

Log in or register to read this article in full and gain access to The Medicine Maker’s entire content archive. It’s FREE!

Receive content, products, events as well as relevant industry updates from The Medicine Maker and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

Register to The Medicine Maker

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Medicine Maker magazine