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Simple and Effective Method for Purification of DMT-ON Oligonucleotides using HIC Resins

INTRODUCTION

The use of synthetic oligonucleotide therapeutics continues to grow because of their effectiveness in the treatment of devastating diseases. Within the biopharmaceutical industry, oligonucleotide drug pipelines have increased significantly, along with the need for purification techniques of these highly valuable materials.

Dimethoxytrityl (DMT), a 5’ protecting group, is used in the synthesis of oligonucleotides to temporarily mask the characteristic chemistry of a 5’-hydroxy functional group. In many preparations of delicate oligonucleotides, DMT may be left on an oligonucleotide following synthesis to give stability to the molecule during subsequent processing.

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