Technology and Equipment

A surge of exciting new cell-based treatments is coming – but is the industry ready?

What do ISPE’s 2016 Facility of the Year Awards tell us about the future direction of the industry?

One year on from winning our inaugural Innovation Awards, we caught up with Niclas Nilsson

The Medicine Maker Innovation Awards are back for the second year to show case the top tech of 2016.

Could star-shaped drug delivery capsules be the solution for ultra-long acting delivery?

Could VR be useful in the design of manufacturing equipment?

Is your viscometer approaching the end of its life? Are you starting to feel that your trial and error, ‘rheology-light’ approach to formulation is becoming dated? Or are there longstanding product performance issues that you’re failing to gain traction with, where you suspect rheology may hold the answer? 

Dry powder inhalers are accepted as being complex drug products due to the interactions which occur between the active pharmaceutical ingredients (APIs) and excipients within the formulation and the way this then affects the efficiency of drug delivery by the inhaler device. Obtaining component specific particle size and particle shape distribution data can help with understanding the properties of the formulation as part of formulation or deformulation studies. This application note describes how the combination of automated image analysis with Raman spectroscopy in the Morphologi G3-ID allows the individual components present within a dry powder inhaler formulations to be independently characterized and compared.

NanoSight instruments can also operate in fluorescence mode where only fluorescently labeled particles are detected and measured. This application note works through an experiment to approximately establish a baseline in terms of the fluorescence limit of detection for a given fluorophore.

Learn how to use DSC to screen for physical stability of proteins in solution.