Solutions for the Separation of Oligonucleotides

contributed by Tosoh | 02/04/2020

Separation of Oligonucleotides from Analytical to Process Scale

The oligonucleotide therapeutics field has seen remarkable progress over the last few years. The first antisense drug was approved and clinical trials using siRNA or splice switching oligonucleotide show promising developments.

The analytical separation of oligonucleotides as well as their purification following synthesis require
special considerations. These have been traditionally met by anion exchange chromatography. Specifically designed resins offer high resolution and selectivity and allow specific oligonucleotide extraction, analysis, purification and polishing.

Tosoh Bioscience offers different product lines for analytical and process scale applications that enable either specific isolation and analysis of oligonucleotides or the process scale purification thereof.

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