Small Molecules

Lyophilized gene networks synthesize biomedicines ondemand – with just a sprinkle of water.

This article explains how an inline probe was used to monitor a granulation at three different scales to confirm that, in each case, the granules produced were the same size, and more importantly produced tablets of identical quality as quantified by hardness.

David Banks offers a warning on using inappropriate lyophilization placebos.

In this article, we take an introductory look at how TDA works, the information it provides and its complementary application to other techniques within the drug development workflow. In addition, example case study data will showcase the performance of TDA relative to dynamic light scattering (DLS) for assessment of the impact of a range of parameters on the monomer-dimer-hexamer equilibrium of insulin.

In this article, triple detection SEC and MDRS are considered within the context of characterizing complex drug formulations, with specific case studies and results illustrating their application.

Predicting and measuring protein aggregation is a critical challenge in the formulation of biopharmaceuticals. This article describes an analytical tool that hits the ‘sweet spot’ of protein aggregation measurement

This article explains how dynamic light scattering (DLS) can be used to gather particle size distribution data for the successful use of nanosized colloidal gold in drug delivery applications.

Large molecules may grab the bulk of industry headlines, but small-molecule drugs are still pulling their weight.

Today’s cleanrooms may meet current quality standards, but what about the future?

The technology behind cleanrooms is well over 50 years old. Is it time for a makeover?