Drug Delivery

Zap a tumor with radiation to trigger P-selectin expression, then release the drugloaded nanoparticles.

When it comes to film coating, there’s more than meets the eye. Is the drug or tablet core sensitive to acidity or moisture? What release profile is needed? And finally, how will the patient react to the finished product?

Few oral biologics have made it to market, and though the challenges are well known, the benefits are huge and the task is not impossible. New technologies can help.

Amazing innovation is happening all around us in the pharma industry. We should take the time to look outside of our own unique areas to congratulate the efforts of others.

Tumor cells and phages inspire a new drug delivery method targeting the placenta

Automated image analysis has been combined with Raman spectroscopy to achieve component-specific size and shape analysis of active ingredients, supporting and accelerating the commercialization of both innovator and generic pharmaceutical products.

Which equipment can measure how the particle size delivered by a dry powder inhaler (DPI) changes as a function of applied air flow rate, providing a deagglomeration profile which can be used to compare the performance of different formulations in a device and improve drug delivery.

OMNISEC measures the Critical Quality Attributes of polymeric pharmaceutical excipients with unrivalled sensitivity supporting their efficient use to formulate safe and effective pharmaceutical products.

Measurement and characterization of binding interactions between proteins and low-molecular weight (LMW) ligands are a focus of academic research and drug discovery. Isothermal titration calorimetry directly measures heat released or absorbed in a binding event, providing means for studying protein-small molecule interactions in solution without the need for labeling or immobilization. Importantly, ITC is often utilized to characterize differences in entropic and enthalpic contributions to binding of novel ligands.

In this application note we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how many drug delivery nanoparticles had successfully been loaded with drug molecules.