Technology and Equipment

In this application note we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how many drug delivery nanoparticles had successfully been loaded with drug molecules.

The ability to compare concentration data across users, instruments and sites is a key requirement for many applications. Concentration repeatability and reproducibility are greatly improved with the application of the NTA concentration measurement upgrade, which has also been shown to reduce the influence of user selected capture and analysis settings on measurements. This application note describes the improvement in accuracy and precision of concentration measurements over a wide range of sample sizes, concentrations and materials.

Viscosizer TD provides automated relative viscosity measurements with high reproducibility at low viscosity, to help identify molecules with abnormally high viscosity-concentration profiles at low sample concentrations as early as possible in the development pipeline

Antibody drug conjugates offer a great deal of potential for drug targeting, but what’s the best way of linking drugs and antibodies?

VR is creating a buzz, but is it a game changer or gimmick?

Dr. Bernhard Hladik from SCHOTT breaks down the delamination phenomenon and describes how pharma manufacturers can effectively fight back.

The first switch from batch to continuous manufacturing has been made – and approved by the FDA. Will pharma’s future be continuous?

AAV vectors are a promising tool for gene therapy and regenerative medicine, but only if they can be manufactured efficiently

A “smart” synthetic patch uses live pancreatic cells to painlessly deliver insulin through microneedles – on demand

This application note explores the use of the Morphologi G3-ID for Morphologically-Directed Raman spectroscopy (MDRS) to identify and analyze contaminants including protein aggregates present in a stressed sample of lysozyme, and to compare particles held in suspension within a thin path wet cell with those collected on a filter membrane.