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Welcome to the March issue! How much is a medicine worth? What about a human life? These questions are the focus of this month’s cover feature on cell and gene therapies. Meanwhile in Upfront, researchers develop a new AI platform that aims to harness scientific data for improved drug development, and we ask whether financial relationships between oncologists and pharma affect clinical practice in inappropriate ways. In Business, Peter Beavis argues that too many companies are missing out on crucial R&D tax credits; and Angela Osborne reveals how she created her own space in the cell and gene therapy industry, in Profession. We also Sit Down With Dave Tudor, who is working on “grand challenges” at the Medicines Manufacturing Innovation Centre, Scotland, UK.