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Small Molecules

Manufacture Facilities

Fumigation of the Future

| Andrew Ramage

A choice of fumigants are available for fumigating microbiological safety cabinets and high-level containment rooms. One substance that is still used in the industry is formaldehyde, but given that formaldehyde is toxic, carcinogenic and corrosive, you’d be better looking for alternatives.

Manufacture Small Molecules

The Case for Continuous

| Reiner Lemperle

“Batch is best,” according to many in the industry, but when cost reductions and greater efficiencies are a priority, continuous processing is becoming increasingly compelling.

Manufacture Standards & Regulation

Problem Plants

Regulators come down hard on facilities that come up short.

Manufacture Small Molecules

Suspended Amination

Chemists solve a 46-year- old problem to develop a new drug modification method.

Discovery & Development Business Practice

Design and formulation of nanomedicines

In this white paper the specific mechanisms by which nanoparticles are designed and formulated for therapeutic purposes and in which NTA has had a significant part to play is discussed.

Discovery & Development Biosimilars

Taylor Dispersion Analysis explained

Taylor Dispersion Analysis is an ultra-low volume, microcapillary flow technique for sizing and stability of biomolecules in complex solutions, and offers advantages for orthogonal and complementary biophysical characterization measurements.

Discovery & Development Business Practice

Accelerate liquid formulation development for protein biopharmaceuticals

The work presented here illustrates how Differential Scanning Calorimetry (DSC) is used in the early stages of protein characterization to rapidly provide critical data about protein stability that can be used as a guide to support and accelerate liquid formulation.

Discovery & Development Business Practice

Reverse engineering of a pharmaceutical formulation

The Morphologi G3-ID can be used to generate component-specific particle size and shape data required to aid the reverse engineering of solid oral dose formulations. Here, we provide an example case study for a powder formulation.

Manufacture Technology and Equipment

Layer by Layer

Does the fabrication of nanoparticles and nanocapules sound complex? Don’t worry – layer by layer technology allows for simple fabrication of complicated stuff.

Manufacture Small Molecules

Precision Medicine; Imprecise Manufacturing and Supply

Precision medicine holds much promise; are companies up to the challenge?

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