Drug Delivery

In an industry as diverse as pharmaceuticals, there is much that different disciplines can learn from each another.

Could an ionic liquid–drug system help solve drug insolubility?

How to dress drugs to help them survive in the bloodstream.

Can lettuce really help biopharmaceuticals turn over a new leaf? Researchers certainly think so.

In this report, we illustrate the utility of calorimetry in making better laboratory decisions.

A case study involving the formulation development of a monoclonal antibody is presented to detail the utility and potential limitations of DSC in support of preformulation for a variety of protein products.

In Part Four, we address frequently asked questions related to the application of DLS to the characterization of protein therapeutic formulations.

In Part Three, we cover the basic types of DLS deconvolution algorithms used to extract the intensity weighted particle size distribution from the measured correlogram.

In Part Two, we cover the influence of concentration effects and particle interactions on DLS results and provide a roadmap for identifying and distinguishing each type of concentration effect.

In Part One, we provide an overview of the key principles of DLS: theory, correlation statistics, deconvolution algorithms, and the intensity to mass transform.