Formulation

Work performed in conjunction with Spiber Technologies, Uppsala, Sweden. Use of dynamic and electrophoretic light scattering to assess the effects of protein formulation composition

Industry is beginning to appreciate how formulation microstructure makes a fundamental contribution to dermal drug delivery – and this new understanding emphasizes the key role of excipients.

Solubility is a key for drug delivery but pipelines are full of compounds with poor solubility.

The stability of drug formulations is essential. But what should be monitored – and how often?

3D printing is starting to sound attractive - but we really need to understand our powders.

In this white paper the specific mechanisms by which nanoparticles are designed and formulated for therapeutic purposes and in which NTA has had a significant part to play is discussed.

Taylor Dispersion Analysis is an ultra-low volume, microcapillary flow technique for sizing and stability of biomolecules in complex solutions, and offers advantages for orthogonal and complementary biophysical characterization measurements.

The work presented here illustrates how Differential Scanning Calorimetry (DSC) is used in the early stages of protein characterization to rapidly provide critical data about protein stability that can be used as a guide to support and accelerate liquid formulation.

The Morphologi G3-ID can be used to generate component-specific particle size and shape data required to aid the reverse engineering of solid oral dose formulations. Here, we provide an example case study for a powder formulation.

Many drug candidates are as poorly soluble as “brick dust”, making oral delivery a significant challenge.