Discovery & Development

The rapid growth of the therapeutic antibody market has increased the interest in modeling of the antibody structure...

In this report, we illustrate the utility of calorimetry in making better laboratory decisions.

This study shows how rheology and particle size measurements can be used to characterize the physical properties of HA dermal fillers.

A case study involving the formulation development of a monoclonal antibody is presented to detail the utility and potential limitations of DSC in support of preformulation for a variety of protein products.

In Part Four, we address frequently asked questions related to the application of DLS to the characterization of protein therapeutic formulations.

In Part Three, we cover the basic types of DLS deconvolution algorithms used to extract the intensity weighted particle size distribution from the measured correlogram.

In Part Two, we cover the influence of concentration effects and particle interactions on DLS results and provide a roadmap for identifying and distinguishing each type of concentration effect.

In Part One, we provide an overview of the key principles of DLS: theory, correlation statistics, deconvolution algorithms, and the intensity to mass transform.

Use of a novel combination of dynamic light scattering and Raman spectroscopy to elucidate the conformational stability and structure of proteins in biopharmaceutical formulations

Javier Morales tells us why he is investigating inkjet printing for the development of buccal films for the delivery of biologic drugs.