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February 2015 Issue of The Medicine Maker

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Articles featured in this issue

Business & Regulation Business Practice

Collaborate or Stagnate

| Charlotte Barker

Can pharma get over its IP anxiety and embrace meaningful partnerships?

Manufacture Bioprocessing - Upstream & Downstream

How Do You Like Your Eggs?

| Charlotte Barker

Scientists in California have ‘unboiled’ an egg – with some interesting implications for biopharma...

Business & Regulation Business Practice

Orphan Affordability

| Stephanie Sutton

Research into rare diseases is on the rise, but are prices sustainable?

Business & Regulation Standards & Regulation

Violation Without Intent?

| Stephanie Sutton

The FDA is not impressed with data mishaps or missing petri dishes – however unintentional...

Business & Regulation Business Practice

Pfizer-Fuelled Rumors

| Charlotte Barker

Could the Pfizer–Hospira deal be a stepping stone to a company split?

Business & Regulation Standards & Regulation

Good Things Come in Small Packages

| Charlotte Barker

Is early and regular dialogue with regulatory agencies the key to success for smaller companies?

Business & Regulation Business Practice

Who Are the Most Powerful Medicine Makers?

| Charlotte Barker

Only you have the answer. Nominate now.

Manufacture Advanced Medicine

Better, Faster, CRISPR

| Stephanie Sutton

Pharma companies look to new genetic screening technology to enhance drug discovery

Manufacture Small Molecules

Rise of the Machines

| Stephanie Sutton

A ‘robot scientist’, capable of independently carrying out drug screening research, has been developed by UK researchers.

Manufacture Advanced Medicine

A Personal Question

| Claire Thompson

Can nanotechnology pick up where personalized medicine leaves off?

Manufacture Small Molecules

Classifying Manufacture

| Michael Leane

A classification system could make the R&D–manufacturing interface much easier to navigate.

Discovery & Development Clinical Trials

Women on the Verge of a Clinical Breakthrough

Women’s health used to be considered solely in terms of maternal and reproductive health. Not anymore. As our knowledge of the basic biological differences between the sexes grows, it’s clear we must take action to ensure women are represented throughout the drug development process.

Manufacture Technology and Equipment

Who’s Developing Your Process?

| Jan Gunnar Gustafsson

Cutting corners in process development will come back to haunt you – especially in the biopharmaceutical arena.

Manufacture Business Practice

Meet The Green Team

| Andy Wells

Pushing for cleaner, greener manufacturing is not only good for the planet, it’s great for business. But it’s not a task that can be accomplished by one company or organization alone


Chemical Alliances

A multimillion Euro project is pushing green chemistry forward in Europe. The secret of its success? Collaboration, collaboration, collaboration!

Manufacture Small Molecules

How Green is Green?

The rapidly evolving field of green chemistry is concerned with minimization of waste and avoidance of toxic and hazardous substances in the production and application of chemical and pharmaceutical products

Manufacture Small Molecules

Smarter Synthesis

| Leena Otsumaa

Green thinking sometimes seems a long way off for those of us in medicinal chemistry, whose primary aim is to find drug candidates by utilizing chemical optimization.

Manufacture Bioprocessing - Upstream & Downstream

Greening Biopharma

At Genentech, a member of the Roche Group, the Green BioPharma program aims to bring sustainability into R&D labs.

Discovery & Development Ingredients

Sustainable Ingredients

| Daniele Piergentili

Climate change, health challenges, and resource inefficiencies or shortages are very high on the agenda of societies around the world. And rightly so

Manufacture Business Practice

A Fresh Pair of Eyes

| Stephanie Sutton

Global healthcare company GlaxoSmithKline (GSK) has pledged to be carbon neutral by 2050. As one of the steps towards this goal, GSK’s Engineering Centre of Excellence has developed and led Energy Reduction Events across all of its global sites.

Discovery & Development Formulation

Dare to Be Different

| Charlotte Miller

With regulators looking for more differentiation between tablets, we must be bolder with solid dosage designs. There’s a whole world of color and shape out there – let’s give our vanilla world a makeover.

Manufacture Ingredients

Model Manufacturing

Our ‘dynamic flowsheet model’ links API purification and processing with downstream tablet manufacturing to provide better control of the process variables and, ultimately, the critical quality attributes of the final pharmaceutical product. Here’s how.

Manufacture Drug Delivery

Nanotechnology Versus Cancer

| Ronak Savla

With only one approved drug and many failures, the cancer vaccine field has lost some of its shine. Could nanotechnology brighten its prospects?

Manufacture Business Practice

Smooth Operator

Sitting Down With… James Christie, Project Director for Manufacturing, Association of the British Pharmaceutical Industry (ABPI), London, UK.

Other issues of 2015